WARNING/Warning: Although it might be exceptional, some people could have quite negative and in some cases deadly Unwanted effects when having a drug. Tell your health care provider or get clinical help immediately Should you have any of the subsequent indicators or symptoms Which might be related to an incredibly lousy aspect impact:

It's not at all acknowledged whether or not this drugs will damage an unborn child. Explain to your medical professional When you are pregnant or plan to be Expecting.

enasidenib will enhance the level or effect of modafinil by influencing hepatic enzyme CYP2C19 metabolism. Use Caution/Keep an eye on. Enasidenib (a weak CYP2C19 inhibitor) may perhaps improve systemic exposure of sensitive CYP2C19 substrates. Watch and regulate dose of substrate as clinically indicated.

apalutamide will decrease the level or impact of modafinil by influencing hepatic enzyme CYP2C19 metabolism. Stay clear of or Use Alternate Drug. Coadministration of apalutamide, a powerful CYP2C19 inducer, with prescription drugs that are CYP2C19 substrates can result in reduced exposure to these medicines.

acetazolamide will enhance the degree or effect of modafinil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Importance Mysterious.

Keep an eye on INR far more commonly if coadministered with inhibitors of such isoenzymes and regulate warfarin dose if desired.

Restrictions of Use In OSA, modafinil tablets are indicated to deal with extreme sleepiness instead of as procedure with the fundamental obstruction. If steady good airway pressure (CPAP) will be the procedure of option for a individual, a maximal work to take care of with CPAP for an enough stretch of time needs to be made previous to initiating and during treatment with modafinil tablets for abnormal sleepiness. two DOSAGE AND ADMINISTRATION

modafinil will raise the degree or result of diazepam buccal by affecting hepatic enzyme CYP2C19 metabolism. Use Caution/Monitor. Potent or average CYP2C19 inhibitors may possibly lower charge of diazepam elimination, thus rising adverse reactions to diazepam.

In case you are taking modafinil to take care of sleepiness attributable to obstructive sleep apnea, You may additionally be taken care of having a continual good airway tension (CPAP) device.

Modafinil has consistently been shown to successfully stop excessive daytime sleepiness without disrupting regular nighttime slumber, which makes it an extremely precious cure for people with narcolepsy‍[seven] or associated slumber Problems which include obstructive rest apnea.‍[eight]

B: Could be acceptable. Possibly animal reports display no hazard but human reports not out there or animal reports confirmed minor threats and human reports carried out and confirmed no threat.

In contrast to amphetamine and also other central anxious stimulants that induce wakefulness by general widespread neuronal activation, modafinil activates neurons selectively, focusing primarily on the hypothalamus and amygdala.

Impact of coadministration of a twin CYP3A4 and CYP2C19 inhibitor with fedratinib hasn't been examined.

Melding av bivirkninger Kontakt lege, apotek eller sykepleier dersom du opplever bivirkninger. Dette gjelder også bivirkninger som ikke er nevnt i pakningsvedlegget. Du kan også melde fra om bivirkninger direkte by means of meldeskjema som finnes modafinil norge på nettsiden til Direktoratet for medisinske produkter: ​/​pasientmelding. Ved å melde fra om bivirkninger bidrar du med informasjon om sikkerheten ved bruk av dette legemidlet. Les avsnitt five. Hvordan du oppbevarer Modiodal Oppbevares utilgjengelig for barn. Bruk ikke dette legemidlet etter utløpsdatoen som er angitt på gjennomtrykksfolien og kartongen etter «EXP».